Ultrasmall Folate Receptor Alpha Targeted Enzymatically Cleavable Silica Nanoparticle Drug Conjugates Augment Penetration and Therapeutic Efficacy in Models of Cancer
Fei Wu, Pei-Ming Chen, Thomas C. Gardinier, Melik Z. Turker, Aranapakam M. Venkatesan, Vaibhav Patel, Tin Khor, Michelle S. Bradbury, Ulrich B. Wiesner, Gregory P. Adams, Geno Germano, Feng Chen*, and Kai Ma.
Molecular Engineering of Surface Functional Groups Enabling Clinical Translation of Nanoparticle–Drug Conjugates
Fei Wu, Thomas C. Gardinier, Melik Z. Turker, Feng Chen, Pei-Ming Chen, Aranapakam M. Venkatesan, Vaibhav Patel, Gregory P. Adams, Michelle S. Bradbury, Ulrich B. Wiesner, Geno Germano, and Kai Ma* Chem. Mater. 2022, 34, 12, 5344–5355
ELU001, a targeted C’Dot drug conjugate (CDC) for the treatment of folate receptor alpha (FRα) overexpressing cancers
Gregory P. Adams, Kai Ma, Aranapakam Venkatesan, Feng Chen, Fei Wu, Melik Turker, Thomas Gardinier, Peiming Chen, Vaibhav Patel, Eliel Bayever, Paul Rudick and Geno Germano. Elucida Oncology, Monmouth Junction, NJ
Molecular Engineering of Ultrasmall Silica Nanoparticle-Drug Conjugates as Lung Cancer Therapeutics
B. Madajewski, F. Chen, B. Yoo, M. Turker, K. Ma, L. Zhang, P.-M. Chen, R. Juthani, V. Aragon-Sanabria, M. Gonen, C. Rudin, U. Wiesner, M. Bradbury, C. Brennan, Clin. Cancer Res.26, 5424–5437(2020).
Ultrasmall Targeted Nanoparticles with Engineered Antibody Fragments for Imaging Detection of HER2-overexpressing Breast Cancer
F. Chen, K. Ma, B. Madajewski, L. Zhuang, L. Zhang, K. Rickert, M. Marelli, B. Yoo, M. Turker, M. Overholtzer, T. Quinn, M. Gonen, P. Zanzonico, A. Tuesca, M. Bowen, L. Norton, J. Subramony, U. Wiesner, M. Bradbury, Nat. Comm., 9, 4141 (2018).
Intraoperative mapping of sentinel lymph node metastases using a clinically translated ultrasmall silica nanoparticle
M.S. Bradbury, M. Pauliah, P. Zanzonico, U. Wiesner, and S. Patel, WIREs Nanomed. Nanobiotechnol., 8, 535–553 (2016).
Clinical Translation of an Ultrasmall Inorganic Optical-PET Imaging Nanoparticle Probe
Phillips, O. Penate-Medina, P.B. Zanzonico, R.D. Carvajal, P. Mohan, Y. Ye, J. Humm, M. Gönen, H. Kaligian, H. Schöder, H. W. Strauss, S.M. Larson, U. Wiesner, M.S. Bradbury, Science Transl. Med., 6 260 (2014).
Clinically-Translated Silica Nanoparticles as Dual-Modality Cancer-Targeted Probes for Image-Guided Surgery and Interventions
S. Bradbury, E. Phillips, P. H. Montero, S. M. Cheal, H. Stambuk, J. C. Durack, C. T. Sofocleous, R. J. Meester, U. Wiesner, S. Patel, Integr. Biol., 5 , 74-86 (2013).